The antihypertensive effects of Eucommia ulmoides leaf water/ethanol extracts are chlorogenic acid dependent

Xue-song Wang; Mi-jun Peng; Chun-tao He

Journal of Functional Foods (Jul 2022)

The antihypertensive effects of Eucommia ulmoides leaf water/ethanol extracts are chlorogenic acid dependent

Xue-song Wang,
Mi-jun Peng,
Chun-tao He

Affiliations

Xue-song Wang: Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology, Guangdong Provincial Engineering Research Center for Ambient Mass Spectrometry, Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center, Guangzhou), Guangzhou 510070, China; Corresponding authors at: Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology, Guangdong Provincial Engineering Research Center for Ambient Mass Spectrometry, Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center, Guangzhou), Guangzhou 510070, China (X.S. Wang) and School of Agriculture, Sun Yat-Sen University, Xingang Xi Road 135, Guangzhou 510275, China (C.T. He).
Mi-jun Peng: Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology, Guangdong Provincial Engineering Research Center for Ambient Mass Spectrometry, Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center, Guangzhou), Guangzhou 510070, China
Chun-tao He: School of Agriculture, Sun Yat-Sen University, Xingang Xi Road 135, Guangzhou 510275, China; Corresponding authors at: Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology, Guangdong Provincial Engineering Research Center for Ambient Mass Spectrometry, Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center, Guangzhou), Guangzhou 510070, China (X.S. Wang) and School of Agriculture, Sun Yat-Sen University, Xingang Xi Road 135, Guangzhou 510275, China (C.T. He).

Journal volume & issue: Vol. 94
p. 105129

Abstract

Read online

The antihypertensive effects of Eucommia ulmoides were determined between normal rats and spontaneously hypertensive rats daily gavaged with leaf extracts, bark extract, chlorogenic acid (CGA), and captopril. Significant composition difference between leaf and bark extracts were noted since CGA was only detected in leaf extract. The overall antihypertensive effects ranked as captopril > CGA > leaf extracts > bark extract, indicating the antihypertensive effect of E. ulmoides extract was CGA-dependent. The hypertension related targets of CGA were screened out and ten KEGG pathways of these targets were significantly enriched, indicating CGA took function in antihypertension via multiple biological processes. Molecular docking revealed CGA bound more tightly to hypertension related targets than captopril, indicating CGA positively participated in antihypertension. However, drug-likeness evaluation displayed the bioavailability of CGA was 5 times lower than captopril, which was consistent with dosage difference in animal experimental. Hence, the antihypertensive effect of CGA was bioavailability limited.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords