Camellia oil lowering blood pressure in spontaneously hypertension rats

Abstract

The purpose of this study was to investigate the antihypertensive effect of camellia oil in vivo and its potential ACE-pathway mechanism. The results showed that the contents of oleic acid and linoleic acid in camellia oil were 78.83% and 8.32%, respectively. In vivo experimental results exhibited that both low-dose and high-dose groups significantly reduced the systolic blood pressure (SBP) in acute and long-term administration experiments compared to the control group. Camellia oil with various dosages significantly reduced the angiotensin-converting enzyme (ACE) activities of tissues and the levels of endothelin, renin and angiotensin II in serum. Moreover, camellia oil performed a similar reduction level on SBP of spontaneously hypertension rats (SHRs) for both captopril and olive oil. Overall, camellia oil exert antihypertension effect by modulating the balance of endothelium-derived vasoconstrictor and relaxing factors in serum.

Keywords

• Camellia oil
• Fatty acids
• Antihypertension
• Spontaneously hypertension rats
• Tissue ACE activity
• Serum indices