npj Vaccines (Oct 2024)

An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection

  • Shiho Chiba,
  • Maki Kiso,
  • Shinya Yamada,
  • Kazuhiko Someya,
  • Yoshikuni Onodera,
  • Aya Yamaguchi,
  • Satoko Matsunaga,
  • Ryuta Uraki,
  • Kiyoko Iwatsuki-Horimoto,
  • Seiya Yamayoshi,
  • Fumihiko Takeshita,
  • Yoshihiro Kawaoka

DOI
https://doi.org/10.1038/s41541-024-00988-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 5

Abstract

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Abstract Highly pathogenic avian influenza (HPAI) H5 viruses from different clades have been circulating globally, threatening wild/domestic birds and mammals. Given frequent spillovers and high mortality among mammals, coupled with our inability to predict which clade of H5 virus has pandemic potential, cross-clade protective HPAI H5 vaccines are urgently needed. Here, we demonstrate the applicability of a lipid nanoparticle-based mRNA vaccine modality to induce cross-protective immunity against lethal HPAI virus infection.