Preventive effect of genistein on AOM/DSS-induced colonic neoplasm by modulating the PI3K/AKT/FOXO3 signaling pathway in mice fed a high-fat diet

Abstract

Colon cancer is one of the most prevalent malignancies in the world. The incidence of colon cancer is on the rise, which seriously affects people's physical and mental health. Genistein, the predominant isoflavone found in soy products, has been shown to inhibit carcinogenesis in animal models. However, the molecular mechanisms involved in genistein preventing carcinogenesis are still uncharacterized. This study was aimed to evaluate the preventive effect of genistein-rich diet on azoxymethane/dextran sulfate sodium (AOM/DSS) induced colon cancer in high-fat mice. Contrasted with control group, the addition of genistein can ward off colon cancer. The expression of COX-2, TNF-α and FRAT1 mRNA has decreased in genistein-treated group. Furthermore, genistein-rich diet has inhibited the viability of colon cancer via regulating the expression of PI3K, FOXO3 and AKT. It has been suggested that genistein prevent the colonic neoplasms growth by modulating the PI3K/FOXO3/AKT signaling pathway in mice fed with a high-fat diet.

Keywords

• Colon cancer
• Genistein
• Mechanism
• Preventive effect