Astaxanthin improves skeletal muscle regeneration in CTX-induced injury of HFD-fed obese mice via mitochondrial biogenesis

Mengting Chen; Chenjie Ling; Ying Chen; Haipeng Wang; Yuanyuan Qin; Jiaying Xu; Guochong Chen; Bimin Shi; Liqiang Qin; Jing Yang

Journal of Functional Foods (Apr 2024)

Astaxanthin improves skeletal muscle regeneration in CTX-induced injury of HFD-fed obese mice via mitochondrial biogenesis

Mengting Chen,
Chenjie Ling,
Ying Chen,
Haipeng Wang,
Yuanyuan Qin,
Jiaying Xu,
Guochong Chen,
Bimin Shi,
Liqiang Qin,
Jing Yang

Affiliations

Mengting Chen: Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu, 215006, China; Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, China
Chenjie Ling: Department of Clinical Nutrition, The Fourth Affiliated Hospital of Soochow University, 9 Chongwen Road, Suzhou, Jiangsu, 215123, China
Ying Chen: Department of Neurology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu, 215006, China
Haipeng Wang: Department of Cardiovascular, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu, 215006, China
Yuanyuan Qin: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, China
Jiaying Xu: State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, China
Guochong Chen: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, China
Bimin Shi: Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu, 215006, China
Liqiang Qin: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu, 215123, China; Corresponding authors.
Jing Yang: Department of Clinical Nutrition, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu, 215006, China; Corresponding authors.

Journal volume & issue: Vol. 115
p. 106114

Abstract

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Obesity impairs the health and regeneration of skeletal muscle. Astaxanthin (AX) possesses antioxidant and anti-obesity properties, making it possible to improve obesity-associated damages. 42 male C57BL/6J mice were fed a control diet, a high-fat diet (HFD) or a HFD with 0.02 %AX for 16 weeks. Mice were either immediately euthanized (experiment one) or given intramuscular injections of cardiotoxin (CTX) and euthanized on the seventh day (experiment two). The experiment one showed that AX improved grip strength and motor function with reduced fat deposition and elevated SOD in skeletal muscle. The experiment two found that AX increased the expression of proteins related to muscle regeneration and mitochondrial biogenesis. The in vitro experiment of interfering C2C12 myogenic cells with AX suggested that AX promoted myoblast differentiation and mitochondrial biogenesis. In conclusion, astaxanthin improves skeletal muscle health and regeneration in obese mice induced by HFD.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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