ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE)

Abstract

The leaves extract of Rourea coccinea was fractionated, following the bioguided method, to give one phenolic compound named 1-caffeoylquinic acid lactone (1-CQL) (1), isolated from this plant for the first time, and the 3-O-β-D-glucopyranoside of stigmasterol (2). The structure of these compounds was determined. The Minimum Inhibitory Concentrations (MIC) for antisalmonella activity was up to 2000 µg·mL-1 for extract and fractions, and up to 500 µg·mL-1 for compound 1. The half-inhibitory Concentration (IC50) values against Plasmodium falciparum PfDd2 was 92.56 µg·mL-1 for extract and 31.24 to 77.21 µg·mL-1 for fractions. Compound 1 exhibited on the same strain an antiplasmodial activity with an IC50 value of 8.58 µg·mL-1. These results justify the use of this plant in Beninese pharmacopeia for the treatment of several diseases such as malaria.

Keywords

• 1-caffeoylquinic acid lactone
• column chromatography
• ethanol extract
• ic50
• leaves
• mic
• spectroscopic method