Fucoidan ameliorates diabetic skeletal muscle atrophy through PI3K/Akt pathway

Caixia Li; Yaping Liu; Mingzhi Yang; Haoyue Huang; Lulu Tang; Yufan Miao; Wenjie Li; Xing Li

Journal of Functional Foods (Mar 2024)

Fucoidan ameliorates diabetic skeletal muscle atrophy through PI3K/Akt pathway

Caixia Li,
Yaping Liu,
Mingzhi Yang,
Haoyue Huang,
Lulu Tang,
Yufan Miao,
Wenjie Li,
Xing Li

Affiliations

Caixia Li: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Yaping Liu: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Mingzhi Yang: Department of Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Haoyue Huang: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Lulu Tang: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Yufan Miao: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Wenjie Li: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Xing Li: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China; Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China; Corresponding author at: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.

Journal volume & issue: Vol. 114
p. 106076

Abstract

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It has been reported that fucoidan plays a beneficial role in type 2 diabetic mellitus (T2DM). However, it remains obscure if fucoidan has the protective effects on diabetes induced skeletal muscle atrophy. Here, we investigated the effect and mechanism of fucoidan on diabetic muscle atrophy. The results revealed that fucoidan ameliorated the general symptoms of diabetes, alleviated insulin resistance, as well as improved glucose metabolism disorders in vivo and vitro. Moreover, fucoidan also improved the atrophy of skeletal muscle by resisting the reduction of muscle fiber diameter and balance the protein anabolism and catabolism. It is worth noting that these beneficial effects of fucoidan on skeletal muscle atrophy and insulin resistance were abolished by inhibiting PI3K/Akt pathway. Taken together, fucoidan ameliorates diabetic skeletal muscle atrophy at least partially by the PI3K/Akt pathway.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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