Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury (TBI) in rats

Cheng Guang; Yue Zhiwei; Wang Liwen; Miyauchi Yutaka; Suzawa Michiko; Li Shiming; Ho Chi‐Tang; Zhao Hui; Chen Naiyao

Food Science and Human Wellness (Sep 2020)

Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury (TBI) in rats

Cheng Guang,
Yue Zhiwei,
Wang Liwen,
Miyauchi Yutaka,
Suzawa Michiko,
Li Shiming,
Ho Chi‐Tang,
Zhao Hui,
Chen Naiyao

Affiliations

Cheng Guang: Department of Hematology and Tangshan Key Laboratory, Translational Medical Center, North China University of Science and Technology, Tangshan, Hebei 063000, China; Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China
Yue Zhiwei: Department of Hematology and Tangshan Key Laboratory, Translational Medical Center, North China University of Science and Technology, Tangshan, Hebei 063000, China; Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China
Wang Liwen: Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China
Miyauchi Yutaka: Miyauchi Citrus Research Center, Takasaki, Gunma, Japan
Suzawa Michiko: Miyauchi Citrus Research Center, Takasaki, Gunma, Japan
Li Shiming: Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources, Huanggang Normal University, Huanggang, Hubei 438000, China; Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, United States
Ho Chi‐Tang: Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, United States
Zhao Hui: Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China; Corresponding authors.
Chen Naiyao: Department of Hematology and Tangshan Key Laboratory, Translational Medical Center, North China University of Science and Technology, Tangshan, Hebei 063000, China; Corresponding authors.

Journal volume & issue: Vol. 9, no. 3
pp. 229 – 236

Abstract

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Traumatic brain injury (TBI) is closely related to neuro-inflammatory response and causes a complex pathological process and serious consequence. In this study, we explored whether the formatted citrus peel extract gold lotion (GL) could have a therapeutic effect on rats suffered TBI. TBI rat model was prepared by the electric Cortical Contusion Impactor (eCCI) device. Prevention against TBI by GL was assessed by the behavioral, organizational of rats and the molecular markers in the brain injury area. The results showed that GL could reduce nerve damage and neurological dysfunction. The mechanisms probably due to that GL could not only reduce the associated damage markers including GFAP, OX-42, TNF-α, COX-2, NF-κB and TLR4 but also promote the expression of VEGF which is responsible for protecting neuronal cells in the injury area. These findings revealed that GL could be a promising preparation for TBI prevention.

Published in Food Science and Human Wellness

ISSN: 2213-4530 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.sciopen.com/journal/2097-0765

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