New dammarane-type triterpene saponins from Gynostemma pentaphyllum and their anti-hepatic fibrosis activities in vitro

Guohui Shi; Xude Wang; He Zhang; Xiaoshu Zhang; Yuqing Zhao

Journal of Functional Foods (Jun 2018)

New dammarane-type triterpene saponins from Gynostemma pentaphyllum and their anti-hepatic fibrosis activities in vitro

Guohui Shi,
Xude Wang,
He Zhang,
Xiaoshu Zhang,
Yuqing Zhao

Affiliations

Guohui Shi: School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
Xude Wang: School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
He Zhang: College of Life Science, Liaoning University, Sheyang 110036, People’s Republic of China
Xiaoshu Zhang: School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Corresponding authors at: School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China.
Yuqing Zhao: School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Corresponding authors at: School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China.

Journal volume & issue: Vol. 45
pp. 10 – 14

Abstract

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Jiaogulan (Gynostemma pentaphyllum) tea as one functional food has been commercially available over the world. In this study, the chemical constituents and health properties of Gynostemma pentaphyllum (G. pentaphyllum) has been investigated. Three new dammarane-type triterpenes Gypenoside C, Gypenoside D, Gypenoside E as well as twenty-four known compounds were isolated from the total G. pentaphyllum saponins. The structural determination was accomplished with spectroscopic analysis, in particularly 1D, 2D-NMR and HRESIMS. All the isolated compounds were evaluated for inhibition activities of the growth of human Hepatic Stellate Cells (t-HSC/Cl-6) and compounds 2, 9, 10, 17, 24, 25, 26, 27 showed significant cytotoxic activities. Among them, compound 27 exhibited more excellent inhibitory activities whose IC50 value (24.4 μM) was 10-fold lower than positive control silymarin. The discovery of new t-HSC/Cl-6 inhibitors from G. pentaphyllum expands its usage as a functional food.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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