DHA supplementation: A nutritional strategy to improve prenatal Fe homeostasis and prevent birth outcomes related with Fe-deficiency

Javier Diaz-Castro; Jorge Moreno-Fernández; Silvia Hijano; Naroa Kajarabille; Mario Pulido-Moran; Gladys O. Latunde-Dada; Jose A. Hurtado; Manuela Peña; Luis Peña-Quintana; Federico Lara-Villoslada; Julio J. Ochoa

Journal of Functional Foods (Dec 2015)

DHA supplementation: A nutritional strategy to improve prenatal Fe homeostasis and prevent birth outcomes related with Fe-deficiency

Javier Diaz-Castro,
Jorge Moreno-Fernández,
Silvia Hijano,
Naroa Kajarabille,
Mario Pulido-Moran,
Gladys O. Latunde-Dada,
Jose A. Hurtado,
Manuela Peña,
Luis Peña-Quintana,
Federico Lara-Villoslada,
Julio J. Ochoa

Affiliations

Javier Diaz-Castro: Department of Physiology, University of Granada, Spain; Institute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Spain
Jorge Moreno-Fernández: Department of Physiology, University of Granada, Spain; Institute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Spain
Silvia Hijano: Department of Physiology, University of Granada, Spain; Institute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Spain
Naroa Kajarabille: Department of Physiology, University of Granada, Spain; Institute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Spain
Mario Pulido-Moran: Institute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Spain; Department of Biochemistry and Molecular Biology II, University of Granada, Spain
Gladys O. Latunde-Dada: Diabetes and Nutritional Sciences Division, Metal Metabolism Group, Faculty of Life Sciences and Medicine, King's College London, London, UK
Jose A. Hurtado: Department of Neonatology, Hospital Materno Infantil Virgen de las Nieves, Granada, Spain
Manuela Peña: Department of Neonatology, Hospital Materno Infantil Virgen de las Nieves, Granada, Spain
Luis Peña-Quintana: Gastroenterology and Pediatric Nutrition Unit, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas, Spain; Department of Clinical Sciences, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain; CIBER, OBN, Spain
Federico Lara-Villoslada: Research and Development Department, Lactalis Puleva, Granada, Spain
Julio J. Ochoa: Department of Physiology, University of Granada, Spain; Institute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Spain; Corresponding author. Biomedical Research Centre, Health Sciences Technological Park, Institute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Avenida del Conocimiento s/n, Armilla, 18071 Granada, Spain. Tel.: +34 958241000 ext. 20317; fax: +34 958 248959.

Journal volume & issue: Vol. 19
pp. 385 – 393

Abstract

Read online

The effect of maternal DHA supplementation on expression of key genes and proteins involved in Fe metabolism and mineral placenta content was evaluated for the first time. One hundred and ten pregnant women were randomly assigned to one of the groups: control (n = 54, 400 ml/day of the control dairy drink; DHA-supplemented (n = 56, 400 ml/day of the DHA-enriched dairy drink). Placenta DMT1, FPN1, TfR1 and Hamp1 mRNA and protein expressions were analysed. Hepcidin concentration in the mother and umbilical cord and placenta mineral content were assessed. DMT1, FPN1, TfR1 and Hamp1 gene expressions together with serum hepcidin increased in umbilical cord and artery of the DHA-supplemented group. In this group, Fe concentration increased in plasma, umbilical cord vein and artery. Ca concentrations raised in umbilical cord vein and artery, Cu, V and Mn levels. Docosahexaenoic acid (DHA) supplementation improved transplacental Fe homeostasis, enhancing Fe transfer and boosting neonates Fe stores at delivery.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords