Arthrospira platensis prevents contractile reactivity damage in obese rats fed a hypercaloric diet by positive modulating the Rho-A/Rho-kinase pathway, inflammation and oxidative stress

Abstract

Obesity is characterized by excess fat, which favors the development of intestinal diseases. Arthrospira platensis (AP) has been the subject of several studies. However, few studies involve its effects on intestinal reactivity and associated mechanisms of action. The effects of AP and the mechanisms by which the seaweed prevents damage to contractile reactivity in the ileum were evaluated. Rats were fed on standard diet (SD), hypercaloric diet (HCD), or HCD supplemented with AP at a dose of 25 mg/kg (HCD + AP25). The preventive effects of seaweed were associated with positive modulation of the Rho kinase complex (ROCK), nitric oxide (NO), contractile prostanoids, superoxide dismutase (SOD) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase signaling pathways, which may be associated with the presence of gamma linolenic acid (GLA), as the main component of AP. Therefore, AP appears as an adjunct in the prevention of obesity and intestinal diseases.

Keywords

• Arthrospira platensis
• Obesity
• Oxidative stress
• Contractile reactivity