Sea cucumber peptides protect against memory impairment by regulating dopamine/serotonin metabolization and synapse plasticity of mice hippocampus

Zhiqiang Lu; Renzhi lv; Liu Dong; Dong Chen; Songyi Lin.

Journal of Functional Foods (Sep 2023)

Sea cucumber peptides protect against memory impairment by regulating dopamine/serotonin metabolization and synapse plasticity of mice hippocampus

Zhiqiang Lu,
Renzhi lv,
Liu Dong,
Dong Chen,
Songyi Lin.

Affiliations

Zhiqiang Lu: State Key Laboratory of Marine Food Processing and Safety Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Liaoning Engineering Research Center of Special Dietary Food, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China
Renzhi lv: State Key Laboratory of Marine Food Processing and Safety Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Liaoning Engineering Research Center of Special Dietary Food, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China
Liu Dong: State Key Laboratory of Marine Food Processing and Safety Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Liaoning Engineering Research Center of Special Dietary Food, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China
Dong Chen: State Key Laboratory of Marine Food Processing and Safety Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Liaoning Engineering Research Center of Special Dietary Food, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China
Songyi Lin.: State Key Laboratory of Marine Food Processing and Safety Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Liaoning Engineering Research Center of Special Dietary Food, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Corresponding author at: State Key Laboratory of Marine Food Processing and Safety Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China.

Journal volume & issue: Vol. 108
p. 105732

Abstract

Read online

With the increase of social stress and brain aging, memory impairment has become a serious problem. Previous studies have shown preliminary neuroprotective evidence of sea cucumber peptides (SCP) by enhancing behavioral performance and modulating cholinergic system. Here, we further investigated the neuroprotective molecular mechanism of SCP in scopolamine-induced memory impairment mice. Passageway-water-maze and passive-avoidance test revealed that SCP enhanced memory in dose-dependent manner. Therefore, mice hippocampus, derived from high-dose of SCP and Model groups, were analyzed by proteomics. According to the GO functional classification, we further found that SCP increased ACh level, prevent neuronal damage, and improved synapse plasticity. The KEGG pathway enrichment revealed significant up-regulations of dopaminergic/serotonergic synapse and synaptic vesicle cycle, which were validated by key proteins (TH and VMAT2) and downstream mediators (serotonin and dopamine). Overall, this study indicated that SCP protected against memory impairment by improving synapse plasticity and regulating dopamine/serotonin metabolization via TH/VMAT2 pathway.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords