Effects of erinacine A-enriched Hericium erinaceus on elderly hearing-impaired patients: A double-blind, randomized, placebo-controlled clinical trial

Yin-Ching Chan; Tzu-Chun Lin; Chin-Chu Chen; Li-Ya Lee; Wan-Ping Chen; Ya-Zue Liu; Juen-Haur Hwang

Journal of Functional Foods (Oct 2022)

Effects of erinacine A-enriched Hericium erinaceus on elderly hearing-impaired patients: A double-blind, randomized, placebo-controlled clinical trial

Yin-Ching Chan,
Tzu-Chun Lin,
Chin-Chu Chen,
Li-Ya Lee,
Wan-Ping Chen,
Ya-Zue Liu,
Juen-Haur Hwang

Affiliations

Yin-Ching Chan: Department of Food and Nutrition, Providence University, Taichung, Taiwan
Tzu-Chun Lin: Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan
Chin-Chu Chen: Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan; Department of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei, Taiwan; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan
Li-Ya Lee: Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan
Wan-Ping Chen: Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan
Ya-Zue Liu: Department of Food and Nutrition, Providence University, Taichung, Taiwan
Juen-Haur Hwang: Department of Otolaryngology-Head and Neck Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan; Corresponding author at: Department of Otolaryngology-Head and Neck Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Minsheng Road, Dalin, Chiayi 62247, Taiwan.

Journal volume & issue: Vol. 97
p. 105220

Abstract

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We aimed to investigate the effects and mechanisms of Hericium erinaceus (HE) on hearing degeneration. By a double-blind, randomized, clinical trial, all 80 hearing-impaired patients aged 50–79 were randomly divided into the two groups, which received HE mycelia (2000 mg/day) and placebo boluses for eight months, respectively. A student’s t-test was used to evaluate the differences of the average pure tone hearing threshold of all, low, and high frequencies (PTA-all, PTA-low, and PTA-high); speech recognition threshold (SRT); speech discrimination score (SDS); and serum concentrations of brain-derived neurotrophic factor (BDNF) and neurotrophic growth factor (NGF) between the two study groups. Subgroup analysis by age showed that PTA-high-Right, PTA-all-Left, PTA-high-Left, SRT-Right, SRT-Left, and NGF were significantly different between the two groups among patients aged ≧ 65. HE mycelia treatment could ameliorate hearing loss, especially for high frequencies and speech recognition, and increase NGF in patients aged ≧ 65.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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