Lactobacillus fermentum PS150 showed psychotropic properties by altering serotonergic pathway during stress

Yen-Wenn Liu; Jia Sin Ong; Chee Yuen Gan; Boon Yin Khoo; Sawibah Yahaya; Sy Bing Choi; Wai Yee Low; Ying-Chieh Tsai; Min Tze Liong

Journal of Functional Foods (Aug 2019)

Lactobacillus fermentum PS150 showed psychotropic properties by altering serotonergic pathway during stress

Yen-Wenn Liu,
Jia Sin Ong,
Chee Yuen Gan,
Boon Yin Khoo,
Sawibah Yahaya,
Sy Bing Choi,
Wai Yee Low,
Ying-Chieh Tsai,
Min Tze Liong

Affiliations

Yen-Wenn Liu: Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan; Microbiome Research Center, National Yang-Ming University, Taipei 11221, Taiwan
Jia Sin Ong: School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia
Chee Yuen Gan: Centre for Advanced Analytical Toxicology Services, Universiti Sains Malaysia, 11800 Penang, Malaysia
Boon Yin Khoo: Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Penang, Malaysia
Sawibah Yahaya: Malaysia Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, Malaysia
Sy Bing Choi: School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia
Wai Yee Low: School of Data Sciences, Perdana University, 43400 Selangor, Malaysia; The Davies Research Centre, School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy, SA 5371, Australia
Ying-Chieh Tsai: Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan; Microbiome Research Center, National Yang-Ming University, Taipei 11221, Taiwan; Corresponding authors at: Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan (Y.-C. Tsai). School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia (M.T. Liong).
Min Tze Liong: School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia; Corresponding authors at: Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan (Y.-C. Tsai). School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia (M.T. Liong).

Journal volume & issue: Vol. 59
pp. 352 – 361

Abstract

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In order to investigate novel probiotics for brain health improvement, the psychotropic potential of Lactobacillus fermentum PS150 (PS150) was evaluated using a 4-week chronic mild stress (CMS) model in rats. Rats fed with PS150 showed less anxious and depressive behaviour in EPM, OFT and FST compared with negative control rats (P < 0.05). Rats in PS150 group also showed less cognitive deficits as evaluated by MWM and NOR tests compared with negative control rats (P < 0.05). PS150 reversed the decrease of serotonin, elevation of IDO and ameliorated brain degeneration in the rat brain induced by CMS. Lowered interferon-γ gene expression and corticosterone levels in brain and plasma were observed in PS150 group compared with the negative control (P < 0.05). Taken together, PS150 prevented stress-mediated reduction of serotonin and neurodegeneration in the rat brain and helped stressed rats achieved more normal behaviour demonstrating the psychotropic potential of PS150 via the gut-brain axis.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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