Nature Communications (Aug 2022)

Mettl3-mediated mRNA m6A modification controls postnatal liver development by modulating the transcription factor Hnf4a

  • Yan Xu,
  • Zhuowei Zhou,
  • Xinmei Kang,
  • Lijie Pan,
  • Chang Liu,
  • Xiaoqi Liang,
  • Jiajie Chu,
  • Shuai Dong,
  • Yanli Li,
  • Qiuli Liu,
  • Yuetong Sun,
  • Shanshan Yu,
  • Qi Zhang

DOI
https://doi.org/10.1038/s41467-022-32169-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

m6A is the most abundant RNA modification of eukaryotic mRNAs and is involved in various physiological and pathological processes. Here the authors show a role for Mettl3-mediated RNA m6A modification in postnatal liver development by regulating the Hnf4a-centered transcriptional network