Nature Communications (May 2022)
Alterations in homologous recombination repair genes in prostate cancer brain metastases
- Antonio Rodriguez-Calero,
- John Gallon,
- Dilara Akhoundova,
- Sina Maletti,
- Alison Ferguson,
- Joanna Cyrta,
- Ursula Amstutz,
- Andrea Garofoli,
- Viola Paradiso,
- Scott A. Tomlins,
- Ekkehard Hewer,
- Vera Genitsch,
- Achim Fleischmann,
- Erik Vassella,
- Elisabeth J. Rushing,
- Rainer Grobholz,
- Ingeborg Fischer,
- Wolfram Jochum,
- Gieri Cathomas,
- Adeboye O. Osunkoya,
- Lukas Bubendorf,
- Holger Moch,
- George Thalmann,
- Charlotte K. Y. Ng,
- Silke Gillessen,
- Salvatore Piscuoglio,
- Mark A. Rubin
Affiliations
- Antonio Rodriguez-Calero
- Department for BioMedical Research, University of Bern
- John Gallon
- Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of Basel
- Dilara Akhoundova
- Department for BioMedical Research, University of Bern
- Sina Maletti
- Department for BioMedical Research, University of Bern
- Alison Ferguson
- Department for BioMedical Research, University of Bern
- Joanna Cyrta
- Department of Pathology, Institut Curie, University Paris Sciences et Lettres
- Ursula Amstutz
- Department of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern
- Andrea Garofoli
- Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel
- Viola Paradiso
- Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel
- Scott A. Tomlins
- Departments of Pathology and Urology, University of Michigan Medical School
- Ekkehard Hewer
- Institute of Pathology, University of Bern
- Vera Genitsch
- Institute of Pathology, University of Bern
- Achim Fleischmann
- Institute of Pathology, University of Bern
- Erik Vassella
- Institute of Pathology, University of Bern
- Elisabeth J. Rushing
- Institute of Neuropathology, University Hospital Zurich
- Rainer Grobholz
- Institute of Pathology, Cantonal Hospital Aarau
- Ingeborg Fischer
- Institute of Pathology, Cantonal Hospital Aarau
- Wolfram Jochum
- Institute of Pathology, Cantonal Hospital St. Gallen
- Gieri Cathomas
- Institute of Pathology, Cantonal Hospital Baselland
- Adeboye O. Osunkoya
- Departments of Pathology and Laboratory Medicine, and Urology, Emory University School of Medicine
- Lukas Bubendorf
- Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel
- Holger Moch
- Department of Pathology and Molecular Pathology, University Hospital Zurich
- George Thalmann
- Department of Urology, Inselspital, Bern University Hospital
- Charlotte K. Y. Ng
- Department for BioMedical Research, University of Bern
- Silke Gillessen
- Faculty of Biomedical Sciences, USI
- Salvatore Piscuoglio
- Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of Basel
- Mark A. Rubin
- Department for BioMedical Research, University of Bern
- DOI
- https://doi.org/10.1038/s41467-022-30003-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
The diagnosis of prostate cancer brain metastasis (PCBM) has increased. Here, the authors investigate the landscape of somatic genetic alterations in brain metastases in a PCBM cohort of 51 patients with non-synchronous matched primary samples available for 20 patients.
