Cell Death and Disease (Nov 2020)
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity
- Amani Bouzidi,
- Maria Chiara Magnifico,
- Alessandro Paiardini,
- Alberto Macone,
- Giovanna Boumis,
- Giorgio Giardina,
- Serena Rinaldo,
- Francesca Romana Liberati,
- Clotilde Lauro,
- Cristina Limatola,
- Chiara Lanzillotta,
- Antonella Tramutola,
- Marzia Perluigi,
- Gianluca Sgarbi,
- Giancarlo Solaini,
- Alessandra Baracca,
- Alessio Paone,
- Francesca Cutruzzolà
Affiliations
- Amani Bouzidi
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Maria Chiara Magnifico
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Alessandro Paiardini
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Alberto Macone
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Giovanna Boumis
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Giorgio Giardina
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Serena Rinaldo
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Francesca Romana Liberati
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Clotilde Lauro
- Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome
- Cristina Limatola
- Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome
- Chiara Lanzillotta
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Antonella Tramutola
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Marzia Perluigi
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Gianluca Sgarbi
- Department of Biomedical and Neuromotor Sciences, University of Bologna
- Giancarlo Solaini
- Department of Biomedical and Neuromotor Sciences, University of Bologna
- Alessandra Baracca
- Department of Biomedical and Neuromotor Sciences, University of Bologna
- Alessio Paone
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- Francesca Cutruzzolà
- Department of Biochemical Sciences A. Rossi Fanelli, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome
- DOI
- https://doi.org/10.1038/s41419-020-03215-0
- Journal volume & issue
-
Vol. 11,
no. 11
pp. 1 – 14
Abstract
Lung cancer is a very aggressive tumor that often forms brain metastases. We show that lung cancer cells motility, fundamental for the formation of metastases, is controlled by amino acids such as serine and glycine, abundant in brain microenvironment.
