Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate

Yang He; Mengdi Wei; Yan Wu; Huaping Qin; Weinan Li; Xiaolin Ma; Jingjing Cheng; Jinshuai Ren; Ye Shen; Zhong Chen; Binggui Sun; Fu-De Huang; Yi Shen; Yu-Dong Zhou

doi:10.1038/s41467-019-09114-z

Nature Communications (Mar 2019)

Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate

Yang He,
Mengdi Wei,
Yan Wu,
Huaping Qin,
Weinan Li,
Xiaolin Ma,
Jingjing Cheng,
Jinshuai Ren,
Ye Shen,
Zhong Chen,
Binggui Sun,
Fu-De Huang,
Yi Shen,
Yu-Dong Zhou

Affiliations

Yang He: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Mengdi Wei: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Yan Wu: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Huaping Qin: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Weinan Li: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Xiaolin Ma: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Jingjing Cheng: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Jinshuai Ren: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Ye Shen: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Zhong Chen: Department of Pharmacology, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University
Binggui Sun: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Fu-De Huang: Center for Stem Cell and NanoMedicine, Laboratory for System Biology, Shanghai Advanced Research Institute, Chinese Academy of Sciences
Yi Shen: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Yu-Dong Zhou: Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-09114-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 18

Abstract

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The underlying mechanism of amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release remains unclear. Here, authors show that the release probability at the synapse between the Schaffer collateral and CA1 pyramidal neurons is significantly reduced at an early stage in mouse models of AD with elevated Aβ production and is mainly due to an mGluR5-mediated depletion of PIP2 in axons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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