Circadian rhythm of blood pressure restoration and nephrotic proteinuria alleviation in a patient with chronic kidney disease after renal sympathetic denervation

Abstract

Renal sympathetic denervation (RSD) could be an effective antihypertensive treatment of resistant hypertension that triggers additional positive effects on glucose metabolism and insulin sensitivity in type 2 diabetes mellitus. We report the effects of RSD in a patient with chronic kidney disease, type 2 diabetes mellitus and resistant hypertension, manifesting as blood pressure reduction with dipping pattern restoration, followed by nephrotic proteinuria alleviation. The non-dipping blood pressure pattern and proteinuria increase the risk of cardiovascular complications and accelerate kidney disease progression. Thus, further research documenting the frequency and investigating the mechanisms of these effects reported after RSD in chronic kidney disease patients with type 2 diabetes mellitus and resistant hypertension is necessary for the benefit of this high-risk patient population.

Keywords

• Circadian rhythm
• Diabetic nephropathies
• Proteinuria
• Hypertension – drug therapy
• Kidney – innervation
• Sympathectomy – methods