Association Between Triglyceride-Glucose Index and Risk of Metabolic Dysfunction-Associated Fatty Liver Disease: A Cohort Study

Abstract

Ru Zhang,1,* Qing Guan,1,* Mengting Zhang,1 Yajie Ding,1 Zongzhe Tang,1 Hongliang Wang,2 Wei Zhang,3 Yue Chen,1 Rong Jiang,1 Yan Cui,1 Jie Wang1 1School of Nursing, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of General Practice, Community Health Service Center, Nanjing, People’s Republic of China; 3Department of Epidemiology, Shanghai Cancer Institute, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Wang; Yan Cui, School of Nursing, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, Jiangsu, 211166, People’s Republic of China, Tel [phone], Email [email protected]; [email protected]: Insulin resistance (IR) is a major factor involved in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD). Triglyceride-glucose (TyG) index, an easily detected surrogate marker of IR, has not been explored sufficiently on its relationship with incident MAFLD risk. This study sought to investigate the association of baseline TyG index with the risk of MAFLD in a Chinese cohort.Methods: This health check-up cohort was constructed with eligible 2056 Chinese from a community. The TyG index was calculated as ln (fasting triglyceride [mg/dL]×fasting glucose [mg/dL]/2). Cox proportion hazard models were used to evaluate the longitudinal association between baseline TyG index and the risk of MAFLD.Results: During an average follow-up of 2.5 ± 0.5 years, about 12.8% of the subjects developed MAFLD, and the incidence of MAFLD trended to increase with the quartile TyG index (Ptrend < 0.05). After adjusting for all confounders, TyG index was independently correlated with the risk of incident MAFLD (HR = 1.784, 95% CI = 1.383– 2.302, P < 0.001), and the risk of MAFLD in the highest quartile of TyG index was two times higher than that in the lowest quartile (95% CI = 1.377– 2.992, P = 0.001). The restricted cubic spline analysis showed that the relationship between TyG index and the risk of MAFLD was linear in males (P for total < 0.001; P for non-linearity = 0.746), but nonlinear in females (P for non-linearity = 0.040).Conclusion: A high baseline TyG index was independently associated with a high risk of incident MAFLD, and we might develop the strategy of MAFLD prevention based on the TyG index.Keywords: triglyceride-glucose index, metabolic dysfunction-associated fatty liver disease, insulin resistance, risk, cohort study

Keywords

• triglyceride-glucose index
• metabolic dysfunction-associated fatty liver disease
• insulin resistance
• risk
• cohort study