Nature Communications (Nov 2021)
Organ-specific genome diversity of replication-competent SARS-CoV-2
- Jolien Van Cleemput,
- Willem van Snippenberg,
- Laurens Lambrechts,
- Amélie Dendooven,
- Valentino D’Onofrio,
- Liesbeth Couck,
- Wim Trypsteen,
- Jan Vanrusselt,
- Sebastiaan Theuns,
- Nick Vereecke,
- Thierry P. P. van den Bosch,
- Martin Lammens,
- Ann Driessen,
- Ruth Achten,
- Ken R. Bracke,
- Wim Van den Broeck,
- Jan Von der Thüsen,
- Hans Nauwynck,
- Jo Van Dorpe,
- Sarah Gerlo,
- Piet Maes,
- Janneke Cox,
- Linos Vandekerckhove
Affiliations
- Jolien Van Cleemput
- HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University
- Willem van Snippenberg
- HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University
- Laurens Lambrechts
- HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University
- Amélie Dendooven
- Department of Pathology, Ghent University Hospital, Ghent University
- Valentino D’Onofrio
- Faculty of Medicine and Life Sciences, Hasselt University
- Liesbeth Couck
- Department of Morphology, Faculty of Veterinary Medicine, Ghent University
- Wim Trypsteen
- HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University
- Jan Vanrusselt
- Department of Radiology, Jessa hospital
- Sebastiaan Theuns
- PathoSense BV
- Nick Vereecke
- PathoSense BV
- Thierry P. P. van den Bosch
- Department of Pathology, Erasmus MC
- Martin Lammens
- Department of Pathology, Antwerp University Hospital
- Ann Driessen
- Department of Pathology, Antwerp University Hospital
- Ruth Achten
- Department of Pathology, Antwerp University Hospital
- Ken R. Bracke
- Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent University
- Wim Van den Broeck
- Department of Morphology, Faculty of Veterinary Medicine, Ghent University
- Jan Von der Thüsen
- Department of Pathology, Erasmus MC
- Hans Nauwynck
- Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University
- Jo Van Dorpe
- Department of Pathology, Ghent University Hospital, Ghent University
- Sarah Gerlo
- HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University
- Piet Maes
- Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- Janneke Cox
- Faculty of Medicine and Life Sciences, Hasselt University
- Linos Vandekerckhove
- HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University
- DOI
- https://doi.org/10.1038/s41467-021-26884-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Here the authors provide a detailed virological analysis of thirteen postmortem COVID-19 cases, including presence of replication-competent SARS-CoV-2 in extrapulmonary organs and tissue-specific patterns of SARS-CoV-2 genome diversity of an immunocompromised patient.
