Molecules (Nov 2020)
Monitoring Methylmalonic Aciduria by NMR Urinomics
- Alina Nicolescu,
- Daniela Blanita,
- Chiril Boiciuc,
- Victoria Hlistun,
- Mihaela Cristea,
- Dorina Rotaru,
- Ludmila Pinzari,
- Ana Oglinda,
- Adela Stamati,
- Isabela Tarcomnicu,
- Andreea Tutulan-Cunita,
- Danae Stambouli,
- Sergiu Gladun,
- Ninel Revenco,
- Natalia Uşurelu,
- Calin Deleanu
Affiliations
- Alina Nicolescu
- “Petru Poni” Institute of Macromolecular Chemistry, Romanian Academy, Aleea Grigore Ghica Voda 41A, RO-700487 Iasi, Romania
- Daniela Blanita
- Institute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, Moldova
- Chiril Boiciuc
- Institute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, Moldova
- Victoria Hlistun
- Institute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, Moldova
- Mihaela Cristea
- “Petru Poni” Institute of Macromolecular Chemistry, Romanian Academy, Aleea Grigore Ghica Voda 41A, RO-700487 Iasi, Romania
- Dorina Rotaru
- “Gheorghe Palade” City Clinical Hospital, Str. Melestiu 20, MD-2001 Chisinau, Moldova
- Ludmila Pinzari
- Institute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, Moldova
- Ana Oglinda
- “Nicolae Testemitanu” State University of Medicine and Pharmacy, Bd. Stefan cel Mare si Sfint 165, MD-2004 Chisinau, Moldova
- Adela Stamati
- “Nicolae Testemitanu” State University of Medicine and Pharmacy, Bd. Stefan cel Mare si Sfint 165, MD-2004 Chisinau, Moldova
- Isabela Tarcomnicu
- Cytogenomic Medical Laboratory, Calea Floreasca 35, RO-014453 Bucharest, Romania
- Andreea Tutulan-Cunita
- Cytogenomic Medical Laboratory, Calea Floreasca 35, RO-014453 Bucharest, Romania
- Danae Stambouli
- Cytogenomic Medical Laboratory, Calea Floreasca 35, RO-014453 Bucharest, Romania
- Sergiu Gladun
- Institute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, Moldova
- Ninel Revenco
- “Nicolae Testemitanu” State University of Medicine and Pharmacy, Bd. Stefan cel Mare si Sfint 165, MD-2004 Chisinau, Moldova
- Natalia Uşurelu
- Institute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, Moldova
- Calin Deleanu
- “Petru Poni” Institute of Macromolecular Chemistry, Romanian Academy, Aleea Grigore Ghica Voda 41A, RO-700487 Iasi, Romania
- DOI
- https://doi.org/10.3390/molecules25225312
- Journal volume & issue
-
Vol. 25,
no. 22
p. 5312
Abstract
The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented.
Keywords
